Lee, H., Deng, M., Sun, F., and Chen, T. (2005) Assessment of the Reliability of Protein-Protein Interactions Using Protein Localization and Gene Expression Data. BIOINFO 2005, Busan, Korea.

Assessment of the Reliability of Protein-Protein Interactions Using Protein Localization and Gene Expression Data

  • Author : Hyunju Lee , Minghua Deng, Fengzhu Sun, Ting Chen
  • Published Date : 2005
  • Category : 
  • Place of publication : Journal of Systems and Software

Abstract

Estimating the reliability of protein-protein interaction data sets obtained by high-throughput technologies such as yeast two hybrid assays and mass spectrometry is of great importance. We have developed a maximum likelihood estimation (MLE) method that integrates both protein localization data and gene expression data to estimate the reliability of protein interaction data sets. Through the integration, we obtain more accurate estimates of the reliability of various protein interaction data sets.

Comments are closed.

Post Navigation