Wangin Kim, Sangbin Park, Chanhun Choi, Youg Ran Kim, Inkyu Park, Changseob Seo, Daehwan Youn, Wook Shin, Yumi Lee, Donghee Choi, Mirae Kim, Hyunju Lee, Seonjong Kim, and Changsu Na (2016) Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine, 2016 June 13; 2016:1230294 (IF 1.931) (JCR 2015: 7/24, 29.2%, INTEGRATIVE & COMPLEMENTARY MEDICINE).

Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats.

  • Author :Wangin Kim, Sangbin Park, Chanhun Choi, Youg Ran Kim, Inkyu Park, Changseob Seo, Daehwan Youn, Wook Shin, Yumi Lee, Donghee Choi, Mirae Kim, Hyunju Lee, Seonjong Kim, and Changsu Na
  • Published Date : 2016
  • Category : Bioinformatics and Text Mining 
  • Place of publication : Evidence-Based Complementary and Alternative Medicine

 

Abstract

Ganghwaljetongyeum (GHJTY) has been used as a standard treatment for arthritis for approximately 15 years at the Korean Medicine Hospital of Dongshin University. GHJTY is composed of 18 medicinal herbs, of which five primary herbs were selected and named new Ganghwaljetongyeum (N-GHJTY). The purpose of the present study was to observe the effect of N-GHJTY on arthritis and to determine its mechanism of action. After confirming arthritis induction using complete Freund’s adjuvant (CFA) in rats, N-GHJTY (62.5, 125, and 250 mg/kg/day) was administered once a day for 10 days. In order to determine pathological changes, edema of the paws and weight were measured before and for 10 days after N-GHJTY administration. Cytokine (TNF-α, IL-1β, and IL-6) levels and histopathological lesions in the knee joint were also examined. Edema in the paw and knee joint of N-GHJTY-treated rats was significantly decreased at 6, 8, and 10 days after administration, compared to that in the CFA-control group, while weight consistently increased. Rats in N-GHJTY-treated groups also recovered from the CFA-induced pathological changes and showed a significant decline in cytokine levels. Taken together, our results showed that N-GHJTY administration was effective in inhibiting CFA-induced arthritis via anti-inflammatory effects while promoting cartilage recovery by controlling cytokine levels.

Comments are closed.

Post Navigation