Baeksoo Kim, Jihoon Jo, Jonghyun Han, Chungoo Park* and Hyunju Lee* (2017) In silico re-identification of properties of drug target proteins. BMC Bioinformatics, 31 May 2017;18(Suppl 7):248. (IF: 2.448) (JCR 2016: 10/57, 17.5%, Oncology) ($: co-corresponding authors). (Presented at DTMBIO 2016 in conjuction with CIKM, Indianapolis, USA)

In silico re-identification of properties of drug target proteins.

  • Author : Baeksoo Kim, Jihoon Jo, Jonghyun Han,  Chungoo Park and Hyunju Lee
  • Published Date : 2016
  • Category : Bioinformatics
  • Place of publication : BMC Medical Informatics and Decision Making

 

Abstract

Computational approaches in the identification of drug targets are expected to reduce time and effort in drug development. Advances in genomics and proteomics provide the opportunity to uncover properties of druggable genomes. Although several studies have been conducted for distinguishing drug targets from non-drug targets, they mainly focus on the sequences and functional roles of proteins. Many other
properties of proteins have not been fully investigated. In this study, we first confirm previously known properties of drug targets with a higher statistical power by analyzing larger sets of drugs and targets. We then suggest new properties, such as gene essentiality, gene expression levels, tissue specificity, and solvent accessibility. We predict drug targets based on these features using a support vector machine and
a random forest method. We believe that our study will provide a new aspect in inferring drug-target interactions.

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